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And it will take several weeks for the Zoloft to get out of your system completely - two weeks is nothing really. Homework Help From Home! The Field Library is now offering online bilingual Homework Help from Miss Rebecca for students in 1st through 6th grade!Mar 05, 2021 · One study found that patients who were taking Zoloft for depression and who were overweight lost anywhere from 0.42 pounds per week to 1.06 pounds per week; one participant in the study lost a total of 69 pounds over 36 weeks. However, Zoloft is typically associated with short term weight loss as compared to long term weight loss. However, Zoloft was found to be better tolerated by patients and to cause fewer side effects in patients. Another study, conducted in 2000, compared the effectiveness of Paxil, Zoloft and Prozac, found the three medications to be equally effective and well tolerated. 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